Set inside a pre-war duplex in downtown Manhattan, The Humans follows the course of an evening in which the Blake family gathers to celebrate Thanksgiving. As darkness falls outside the crumbling building, mysterious things start to go bump in the night and family tensions reach a boiling point

　　女星瑞德曾經紅極一時，隨著年齡增長，她的演藝事業開始走下坡，經紀人昆頓也把全部心力集中在照顧更年輕、更當紅的潘妮洛普身上。瑞德決定走險招賭一把，她把電視主持人及攝影師找來，答應給他們一則獨家新聞，當採訪開始時，瑞德拋出一枚震撼彈，她將一把沾滿鮮血的兇刀放在桌上，不僅承認刀子上的血跡正是女星潘妮洛普所有，更表明警方已經在趕來的路上。這一切究竟是怎麼一回事？是瑞德出於忌妒殺了潘妮洛普，還是兇手另有其人？