U Turn is a Mystery Thriller. A young female reporter is upset about how people break traffic rules, she wants to do a story about it and have it published. In this pursuit she finds herself struck in a police case dealing with series of murders. The film is about how she tries to free herself of these accusations and also becomes part of the investigation process. The rest of the film is about the mysterious deaths and how they are all interconnected with a road accident.

　　Despite qualifying for armed force, Karthik ('Jayam ' Ravi) prefers to be a traffic cop in Ooty as he believes that such a no risky job would help him get enough time to look after his cute little sister Vidhya (Baby Anikha). Karthik also has a short lived one side love story with Renu (Lakshmi Menon), who is a doctor. When a hazardous chemical in the nearby industry gets leaked, a dog consumes it and turns into a zombie. As the dog bites a watchman, he too becomes a zombie and eventually, the virus spreads rapidly across the town. Can Karthik save his sister and the city ?